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| Description | TM30089 is a highly potent, selective CRTH2/DP2 antagonist. | ||
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| Targets |
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| In vitro | TM30089, which is structurally closely related to ramatroban, was found to bind mouse CRTH2 with nanomolar affinity and potently inhibit its signaling in cells overexpressing the receptor. In addition, TM30089 completely lacks affinity to the mouse TP receptor, unlike ramatroban which represents a dual TP/CRTH2 antagonist on both human and mouse receptor orthologs[1] | ||
| In vivo | Administration of TM30089 displayed anti-inflammatory efficacy in a mouse model of allergic asthma that mimics some of the major histopathological features characteristic of human asthma such as eosinophilia and mucus cell hyperplasia.[1] |
| Quantity | 1 grams, 5 grams |
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