Powder for Hairloss Treatment Research Archives - TheKaneShop

PF-06700841

andreas — Tue, 28 Apr 2020 08:23:35 +0000

PF-06700841 is a potent inhibitor of Tyk2 and Jak1 with IC50s of 23 nM, 17 nM, 77 nM for Tyk2, Jak1 and Jak2 respectively. It has appropriate in-family selectivity against JAK2 and JAK3.

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Tofacitinib (CP-690550）

andreas — Tue, 28 Apr 2020 08:13:02 +0000

Tofacitinib (CP-690550,Tasocitinib) is a novel inhibitor of JAK3 with IC50 of 1 nM in cell-free assays, 20- to 100-fold less potent against JAK2 and JAK1.

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Ruxolitinib

andreas — Tue, 28 Apr 2020 08:05:41 +0000

Ruxolitinib (INCB018424) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays, >130-fold selectivity for JAK1/2 versus JAK3.

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PF-06651600

andreas — Tue, 28 Apr 2020 07:58:53 +0000

PF-06651600 is a potent and irreversible JAK3-selective inhibitor with an IC50 of 33.1 nM but without activity (IC50 > 10 000 nM) against JAK1, JAK2, and TYK2.

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Baricitinib (LY3009104)

andreas — Tue, 28 Apr 2020 07:49:18 +0000

Baricitinib (LY3009104, INCB028050) is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM in cell-free assays, ~70 and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2. Phase 3.

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SM04554

andreas — Thu, 19 Mar 2020 02:21:40 +0000

SM04554 is a topical compound that modulates the WNT pathway. The WNT pathway is one of the primary signalling pathways that regulate the self-renewal and differentiation of adult stem cells. It also plays other important roles: from hair follicle cycling to hair follicle morphogenesis.

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Equol

andreas — Tue, 30 Apr 2019 01:38:22 +0000

Equol (4′,7-isoflavandiol) is an isoflavandiol metabolized from daidzein, a type of isoflavone found in soybeans and other plant sources, by bacterial flora in the intestines.While endogenous estrogenic hormones such as estradiol are steroids, equol is a nonsteroidal estrogen. However, only about 30-50% of people have intestinal bacteria that make equol. Equol can exist in two enantiomeric forms, (S)-equol and (R)-equol.(S)-Equol preferentially binds estrogen receptor beta.

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S-Equol

andreas — Tue, 30 Apr 2019 01:36:08 +0000

(S)-equol is under development for the treatment of menopausal symptoms such as hot flashes and benign prostatic hyperplasia.

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BIO

andreas — Tue, 30 Apr 2019 01:30:52 +0000

BIO is a cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK3α/β (IC₅₀= 5 nM). Its specificity has been tested against various cyclin-dependent kinases (CDKs) (IC₅₀s = 83, 300, 320, and 10,000 nM for Cdk5/p25, Cdk2/A, Cdk1/B, and Cdk4/D₁, respectively). BIO was also tested for its specificity towards many other commonly studied kinases (IC₅₀ ≥10 µM), including MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK. Inhibition of GSK by BIO has been shown to result in the activation of the Wnt signaling pathway and sustained pluripotency in human and mouse embryonic stem cells (ESCs). BIO is reported to maintain self-renewal in human and mouse ESCs as well as induce the differentiation of neonatal cardiomyocytes.

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RU58841 Raw Powder – Ultra Pure

andreas — Tue, 30 Apr 2019 01:24:34 +0000

RU58841 Raw Powder

Buy The Best Quality RU58841 for research purpose, Exclusive at Anageninc & TheKaneShop

RU58841 is a specific androgen receptor antagonist or a so called anti-androgen. This non steroidal topical androgen antagonist was investigated for therapeutic value in androgenetic alopecia and acne. In studies and clinical trials RU58841 has shown to;

Strongly compete against DHT
Increase cellular replication rate in the matrix cells
Increase cellular proliferation of outer root sheeth cells
Increase hair diameter and hair density
Increase the percentage of hair in the anagen phase
Exert no negative effect on body hormone levels
Provide equivalent or better net growth than Finasteride

RU58841 works by binding to the androgen receptor in the hair follicle. Therefore androgens don’t have the chance to bind and start the chain reaction of androgenetic alopecia and begin the so called miniaturization process. It has been demonstrated to interrupt this hair loss message locally so that normal hair growth could continue.

We at thekaneshop/anageninc provide this compound in a unique stable route of synthesis form which is extremely stable in solid and solution form which has been demonstrated by our R&D laboratory. The results are very encouraging which shows that the current thekaneshop/anageninc route of synthesis is stable for at least 24 months at room temperature.

Quality control:

Full transparency: Each batch is HPLC tested at a third party government controlled lab, reports are included with each order
Test reports: Click here to download the latest lab test reports
Our RU58841 powder is professionally sealed in a waterproof airtight aluminum pouch, for maximum potency and prolonged storage.

This article is intended for educational / informational purposes only. RU58841 IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. PLEASE FAMILIARIZE YOURSELF WITH OUR TERMS & CONDITIONS PRIOR TO ORDERING.

PLEASE FAMILIARIZE YOURSELF WITH OUR TERMS AND CONDITIONS PRIOR TO ORDERING. ANAGEN INC WILL IMMEDIATELY DENY ANY ORDER THAT WE FEEL WILL BE USED OUTSIDE OF THE SCOPE OF IT’S INTENDED PURPOSE.

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