UK-5099 powder Archives - TheKaneShop https://thekaneshop.com/product-tag/uk-5099-powder/ Quality research chemicals Mon, 29 Apr 2019 03:05:39 +0000 en-US hourly 1 https://wordpress.org/?v=6.9.1 UK-5099 https://thekaneshop.com/product/uk-5099/ https://thekaneshop.com/product/uk-5099/#respond Mon, 29 Apr 2019 02:55:52 +0000 https://thekaneshop.com/?post_type=product&p=2545 UK-5099

CAS NO:56396-35-1

Assay: 98%min

Only for research use only

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]]> UK-5099 is a potent inhibitor of the mitochondrial pyruvate carrier (MPC). UK-5099 ihibits pyruvate-dependent O2 consumption with an IC50 of 50 nM.IC50 & Target: IC50: 50 nM (MPC)[1]In Vitro: The trypanosomal pyruvate carrier is found to be rather insensitive to inhibition by alpha-cyano-4-hydroxycinnamate (Ki=17 mM) but can be completely blocked by UK-5099 (Ki=49 microM)[2]. UK-5099 also inhibits the monocarboxylate transporter (MCT) [3]. UK5099 significantly inhibits the glucose-stimulated rise in oxygen consumption in a dose-dependent manner and at 150 μM reduced oxygen consumption below basal levels. UK5099 reduces ATP levels and increases ADP and AMP levels in 832/13 cells[4]. The UK5099 treated cells show significantly higher proportion of side population fraction and express higher levels of stemness markers Oct3/4 and Nanog. UK5099 application may be an ideal

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