No products in the cart.
| Description | Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. | ||
|---|---|---|---|
| Targets |
|
||
| In vitro | Bimatoprost mildly stimulates the rate of aqueous humor flow during the day (13%) and at night (14%), its ocular hypotensive action is due primarily to a 26% reduction in the tonographic resistance to outflow. Bimatoprost enhances the pressure-sensitive outflow pathway. [1] Bimatoprost displaces [3H]prostaglandin F(2alpha) from FP receptors with K(i) of 6.31 μM. Bimatoprost rapidly mobilizes intracellular Ca(2+) via cloned human FP receptors expressed in human embryonic kidney cells and via native FP receptors in 3T3 mouse fibroblasts with EC(50) of 2.94 μM and 2.2 μM. [2] Bimatoprost up-regulates Cyr61 mRNA expression in the cat iris. Bimatoprost-induced up-regulation of Cyr61 mRNA expression is not because of the activation of the prostaglandin FP receptor but a different receptor. [3] Bimatoprost consistently evokes responses in different cells within the same tissue preparation, whereas prostaglandin F(2 alpha) and 17-phenyl prostaglandin F(2 alpha) elicites signaling responses in the same cells. Bimatoprost selectively stimulates intracellular calcium signaling in different cat iris sphincter cells. [4] | ||
| In vivo | Bimatoprost is the ethyl amide derivative of 17-phenyl trinor PGF2α, a potent prostaglandin FP receptor agonist. Bimatoprost elicits an immediate, robust spike in [Ca2+] that rapidly decayes back to baseline levels. Bimatoprost possess direct agonist activities at the rat, mouse, and human FP prostanoid receptor. [5] |
| Quantity | 100 mgs, 500 mgs, 1 grams, 5 grams |
|---|
Be the first to review “Bimatoprost”
Related products
Powder for Hairloss Treatment Research
$25.00 – $75.00
*Sales Promotion for 2022
$120.00 – $700.00
Sale!
Powder for Hairloss Treatment Research
$300.00 – $4,500.00
Sale!
*Sales Promotion for 2022
$100.00 – $1,000.00
New Research Chemicals
$100.00 – $450.00
Sale!
*Sales Promotion for 2022
$100.00 – $550.00
New Research Chemicals
$300.00 – $500.00
Powder for Hairloss Treatment Research
$500.00
Reviews
There are no reviews yet.