KY19382

KY19382 is an effective and orally active dual inhibitor of CXXC5-DVL and GSK3β, with IC50 values of 19 and 10 nM, respectively. KY19382 activates Wnt/β-catenin signaling by inhibiting the interaction between CXXC5 and DVL as well as the activity of GSK3β. KY19382 can be used in research on metabolic disorders induced by a high-fat diet (HFD).